PubMed Latest
This section contains a feed from PubMed with recent papers on 'ciliopathy', with hyperlinked titles.
When you are on the PubMed site, you can search using any cilia and ciliopathy-related keywords or terms.
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PubMed RSS feed: Latest results from PubMed
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Reelin Deficiency Alters the Directional Orientation, Apical Localization and Length of Primary Cilia in Principal Neurons in the Cerebral Cortex
12 November 2026The primary cilia of pyramidal neurons in inside-out laminated regions are oriented predominantly toward the pia, a pattern reflecting reverse soma movement during postnatal neurodevelopment. However, the mechanisms that regulate the directional cilia orientation remain unknown. Here we show that the primary cilia of neocortical pyramidal neurons in male and female mice are localized at the base of the apical dendrites and aligned distally and opposite to the axon initial segment (AIS). However,...
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Budding without an ESCRT
12 November 2026Condensates help drive the budding of vesicles from the tips of cilia.
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ESCRT-0 condensation and cargo clustering drive extracellular vesicle budding from cilia
12 November 2026Cilia-derived extracellular vesicles (EVs) mediate cell-cell communication and remove signaling molecules from cilia. The Hedgehog receptor Smoothened (SMO) is selected for packaging into ciliary EVs by ubiquitin chains, but how cargo selection is coupled to EV budding remains unknown. In this work, working in mouse kidney cells, we found that the ubiquitin reader endosomal sorting complex required for transport-0 (ESCRT-0) orchestrates both cargo selection and EV biogenesis. Unlike the...
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Establishing functional mouse primary nasal epithelia in the air-liquid interface to study bacterial infection
12 November 2026Nasal epithelia are amongst the first lines of defense against airway infections. Development of a robust ex vivo nasal epithelia model will enable further mechanistic study of pathogen-upper airway interaction. While the current human nasal epithelia models are limited by their availability and ethical constraints, there is a lack of a robust mouse nasal epithelia model. Here, we developed a functional mouse primary nasal epithelia (MNE) model in an air-liquid interface (ALI). We described an...
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Assessment of autosomal dominant polycystic kidney disease severity using deep learning-based kidney volumetry in CT
12 November 2026CONCLUSION: The proposed method enables accurate TKV quantification and MIC classification from noncontrast CT, supporting severity assessment and longitudinal monitoring in ADPKD.