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CONCLUSIONS: Our results showed that Anti-miR-21-SNA treatment represents a potential therapeutic strategy for cystic kidney disease.

Biomimetic approach is a nature-driven strategy for designing functional materials to meet the industrial challenges. Here we demonstrate the bio-inspired discovery of a self-activating catalyst, with polydimethylsiloxane anchored over the surface of CrOx/Al2O3, exhibiting comparable performance with noble metallic catalysts for acetylene semi-hydrogenation. In addition, the dynamic movement of polymer chains with high flexibility renders the catalyst to impose proactive perturbation to the...

A new species belonging to an unusual polychaete genus Ctenophoricola is described as Ctenophoricola tzetlini sp. nov.. The new species differs from the two valid species of the genus in body proportions and in having: external eyes with well-developed cornea resembling those in free-living Alciopini, acicular chaetae in the anterior body region, a large pygidium with long anal cirri, and distinct bundles of cilia scattered over the posterior body region. The new species' similarity to an...

INTRODUCTION: Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder affecting motile cilia, leading to impaired mucociliary clearance and increased susceptibility to respiratory infections. These infections contribute to long-term complications such as bronchiectasis and lung function decline.

'En bloc' inheritance of point mutations in adjacent genes has rarely been described. We have previously reported a family with severe, mostly early-lethal, Joubert syndrome (JBTS) with early-onset severe retinal dystrophy (EOSRD) and polycystic kidney disease (PKD), which had then been attributed to a homozygous pathogenic missense variant, p.(Arg106Pro), in the ciliary POC1B gene. Because this and other POC1B variants were in subsequent studies only reported in patients with non-syndromic...